Cou 26:Ptich co che t/dung,ADLS cua thuoc uc che he N cua co van

gom Cura & coc che fam

1.Co che:+t/dung uu tien tren he nicotinic cua cac co xuong ( co van),lam ngan can luong xung tac TK toi co o ban van dong nen lam gion co

+Khi kthich tuong tu co van dap ung dc,cac co ko bi liet cung 1 luc ma lan luot la cac co mi ( gay sup mi),co mat, co co,co chi tren,chi duoi,co bung,cac co lien suon & cuoi cung la co hoanh ->benh nhan ngung ho hap & chet

+ vo t/dung ngan,neu dc ho hap nhan tao,chuc fan cac co se dc hoi fuc theo thu u nguoc lai

+yc che truc tiep lon trung tom hu hap o hành noo -> làm gion mach,ha HA hoac co that kho quan do giai fung histamin

+hau het deu mang amin ba 4 nen rat kho tham vao TKTU,ko hap thu qua thanh ruot

- theo co che t/dung chia lam 2 loai:

+Loai tranh chap voi acetylcholin o ban van dong -> lam ban van dong ko khu cuc dc

+loai t/dung nhu acetylcholin ->lam ban van dong khu cuc qua manh -. tang t/dung cua cac thuoc fong toa cholinerterase

2.ADLS: -Chi dinh: + lam mem co trog fa thuat,trog chinh honh, dat ong noi khi quan

+trog tai - mui - hong: soi thuc quan,gap di vat

+chong co giat trog choang dien,uon van,ngo doc strychnin

-chu y: 1 so thuoc khi dung voi Cura,loai giong cura co the co t/dung hiep dong lam tang t/dung liet co cua Cura,nen can giam lieu:

+ thuoc mo: ete, cyclopropan,halothan

+ Khong sinh: streptomycin,polymycin B, kanamycin,neomycin

+Quinin,quinidin