Cau 32: testosteron: ban chat, tac dung, dieu hoa bai tiet va UDLS

*) nguon goc: chu yeu do tinh hoan bai tiet:

*) Ban chat: la hormon thuoc nhom steroids co 19C dc tong hop tu cholesterol oracetyl_CoA

*) t/d:

a) tren nam gioi:

- trong TK bao thai co t/d biet hoa trung khu so

+ trong TK bao thai biet hoa ong wolf thanh dg SD trong cua nam: mao tinh, ong dan tinh, tui tinh, ong phong tinh

+ giup tinh hoan ha nang (ra khoi o bung)

- sau khi sinh ra (db tuoi day thi): hormon SD giup phat trien ca chieu cao va can nang (t/d len chuyen hoa pr va co dvoi chuyen hoa: tang sx pr, co bap nam phat trien hon nu nho HMSD)

+ HMSD nam lam can nang tang len (giu muoi va nc)

+ HMSD nam xhien va bao ton cac dac tinh SD of nam gioi: da tinh thu phat (sau tuoi day thi moi xh)

FSH phat trien co quan SD chinh

HMSD nam phat trien co quan SD phu 1 phan phat trien tuyen tien liet. Kick thick san sinh tinh trung

- tac dung len xuong: tang tog hop khung pr cua xg:

+ phat trien va cot hoa sun lien hop o dau xg dai

+ lam dai xg

o+ tang lang dong muoi Ca2+ -> tang suc manh cua xg

+ lam hep dg kinh, tang chieu dai khung xg chau

+ tang suc manh cua khung chau

Do tac dung lam tang kick thuoc va suc manh cau xg nen testosterol dc dung de dieu tri lo•ng xg o ng dan ong lon tuoi

- tac dung len chuyen hoa co so:

Voi lg HMSD nam dc bai tiet hang ngay o truoc tuoi thieu nien chuyen hoa co so tang 5 - 10% so voi khi ko co t/d cua testosteron

- tang qua trinh san sinh HC: tang so lg HC trong 1 mm3 mau khoang 20%

- tang nhe su taI hap thu Na+ o ong luon xa

b) tren nu gioi: nong do HMSD nam nho nen t/d ko ro rang. neu qua cao co the gay nam hoa, moc trung ca, co rau, co bap

*) Dieu hao bai tiet

+thoi ky bao thai: testosteron dc bai tiet duoi t/d kick thick cua HCG (hormon do rau thai bai tiet)

+Thoi ky truong thanh: testosteron dc bai tiet duoi t/d kick thick cua LH do tuyen yen bai tiet