Cau 42: ptich co che va tdung cua thuoc chong con dau that nguc nhom nitrat va nitrit

1.Co che tdung:

a.Toc dung:

-Nitrat lam jam moi loai co tron do bat ko ngnhon goy tang truong luc nao, k tac dung truc tiep len co tim va co van

-Tron mach: Nitrat làm jon mach da, mach và mach toàn thon

+Jon tinh mach -> jam dung mou ve tim ( jam tien gonh)

+Jon dong mach -> jam suc can ngoai bien (jam hau ganh)

=>the tich tam thu jam, cong nang co tim jam=> jam sdung O2

-Mat khoc do su fan bo mau cho tim tang va jam theo huong co loi cho vung duoi noi tam mac

-Tren co tron khac: nitrat lam jon fe quan, ong tiou hoo, duong mat, tiet nieu sinh duc

2.Co che:

-Cac nitrat, nitrit jai fong NO duoi tdung cua E

-NO jai fung se hoat hoo guanylyl cyclase -> tang tuan hoan

-GMPC- khu phosphoryl chuoi nhe cua myosin-> goy jon co

-Myosin chuoi nhe lai phosphoryl hoo -> myosin LC-PO4 gay co co

So do

-TDung jon co cua nitrat jong tdung cua yeu to gion co cua tb noi mo EDRF, tb mach mau tiet EDRF la NO hoac tien chat cua NO. EDRF tham tu noi mo mach vao tb co tron thanh mach va biet hoa guanylyl cyclase tai do

-Coc chat noi sinh goy jon mach cu the thung qua co che jai fong ADRF

-vung jon mach fu thuoc vào F và chuyen hoo khoc nhau cua thuoc