Cau 50: TB ve co che, dd TD va AD cua thuoc khang acid tac dung tai cho

Do cac cation cua thuoc nay tao phuc hop base, ko tan, ko hoac rat it hap thu dc vao mau, cho nen ko gay dc tac dung toan than

Magnesi hydroxyd: Mg(OH)2

Cham

Mg(OH)2 + 2HCl ( MgCl2 + 2H2O

Rat it tan trong nuoc. Xuong ruot non Mg2+ tac dong voi anion phosphat va carbonat tao thanh muoi it tan hoac ko tan do do tranh dc su hap thu base, tranh dc base huyet ngay ca khi dung lau.

Do Mg2+ du nuoc len co tac dung tay thuong dung cung voi CaCO3

Nhum hydroxyd: Al(OH)3 - Al2 (OH)6

Cham

Al(OH)3 + 3HCl ( AlCl3 + 3H2O

Nhum hydroxyd là chat keo toc dung trung hua yeu lon ko goy phan ung tang tiet acid hoi ung. Dang nhu dich nuoc, 1ml trung hua dc 1,2 den 2,5 mEq acid. Khi dung lou se:

- Hop voi protein niem mac ruot, lam san, gay tao

- Ket tua pepsin len co tac dung tot trong dieu tri loet do tang pepsin.

-O ruot tao phosphat nhom ko tan hau nhu ko bi hap thu, thai tru theo phan, ko gay base mau. Vo phosphat bi thai tru, co the phai huy dong phosphat tu xuong ra, de gay trung nhuyen xuong, vo vay can an nhieu phosphat va protein.

Nhom hydroxyd lam giam nhu dong duong tieu hoa len thuong dung che pham ket hop.

Khong dung cho nguoi suy than nang.

Cu the làm giam hap thu nhieu thuoc khoc.

Nhon chung coc thuoc khong acid tron cu the nong pH cua da dày lon gan 4 giyp cho su toi tao cua niom mac dc thuan loi hon tuy nhien thoi gian tac dung chi keo dai 15-30p len phai dung nhieu lam