Cau 62: Ve so do tdung len COX_1 va COX_2 cua cac thuoc uc che chon loc tren COX_2

*/Ve so do:

Giai thich COX: enzyme cycloxygenase: xt cho qt a.arachidonic-> PG ton tai ot nhat là 2 isoenzym COX_1 và COX_2.

- COX_1 hay prostaglandin G/H synthetase_1: la enzyme ctao, tgia tog hop cac PG co tac dug bao ve xu on dinh noi moi nhu bve NM da day, chong ngung ket TC, giu cho h/d sli o than bt à COX_1 cun dc goi la enzyme giu nha

- COX_2 hay prostaglandin G/H synthetase_2: la enzyme co knang gay cam ung, nhat la trong cac p/ung viem. Cac kich thich viem hoat hoa COX_2 cua bcau don nhan dai thuc bao tb mang hoat dich tbsun... de tong hop cac PG gay ra cac trieu chung viem

*/Dac diem cua cac thuoc chong viem, tdung uu tien tren COX_2

- uc hce chon loc COX_2 hon len co tdung chong viem manh vo uc che COX_1 yeu len cac tdung phu ve tieu hoa, mau, than, con hen giam ru ret chi cun tu 0.1-1%

- t/2 dài, xap xi 20h à uong 1 lon/ngày

- hap thu de dàng qua dg tieu hoa, de tham vao cac mo va cac dich bao cap len co nong do cao tren mo viem chi dinh tot trong viem khop dang thap

- vo ngung ket tieu cau phu thuoc vao COX_1 len cac khop nhom nay ko dung de du phung nhoi mou co tim( van cun aspirin)