Cau 38. Nh.trung? Cac hinh thai nh.trung...

*nh.trung: la su xam nhap va sinh san vao mo of cac vsv gay benh dan toi su xuat hien or ko xuat hien benh nh.trung

* cac hinh thai nh.trung:

1 benh nh.trung: vsv gay benh gay ra cac roi loan co che dieu hoa of co the-> cac dau hieu nh.trung ro det(sot ,dau) va tim thay cac vsv gay benh trong benh pham. gom 2 lai:

-benh nh.trung cap tinh: trieu chung benh ro det , benh ton tai thoi gian ngan, sau do b.nhan khoi va tu vong

-benh nh.trung man tinh: benh keo dai va trieu chung ko du doi, do cac vsv ky sinh ben trong TB

2. nhiem trung the an; ng bi nh.trung ko co dau hieu lam sang, thuong ko tim thay vsv trong mau benh pham nhung co the co nhung thay doi cong thuc mau,nh.trung the an gap nhieu hon cac benh nh.trung. Hinh thai nh.trung nay ko gay nguy hiem cho b.nhan nhung la nguon gay benh

3. nh.trung tiem tang: vsv vao co the nhung ko sinh san va ptrien, no ton tai trong mot so mo co quan, khi gap dkien thuan loi no lai ptrien gay benh

4. nh.trung cham: do mot so VR, thoi gian u benh rat dai

Cau 39:Cac yeu to tao nen doc luc of VSV.

1, Su ban vao TB

- la dk dau tien de vsv co the xam nhap vao mo va gay nh.trung

-co che do cac phan tu be mat dac hieu of vsv gan voi cac receptor tren be mat Tb cam thu

-cac thanh phan tham gia bam:pili, fimbriae, polysaccharid be mat va cac cau truc bam khac

2. su xam nhap va sinh san:

-la yeu to quyet dinh co hay ko nh.trung

-VK: +tiet ngoai doc to: bach cau

+ xam nhap vao TB: E.cali

+xam nhap vao trong mo,:lao, tu cau vang

-VR:phai chui han vao trong TB

3.Doc to: la nhung chat doc of vav, gom ngoai doc to va noi doc to

4. Enzym:co lien quan den kha nang gay benh , con ban than chung rat it doc tinh .

-hyaluranidase: la yeu to xam nhap

-coagulase: nhan can su thuc bao va tac dung of KT,KS

-streptokinase: lam tan to huyet->tang su lan tran of VK

-hemolyzin: co y nghia trong chuan doan vsv

-protease: thuy phan Tg.A1

5. mot so HN be mat :chong lai su thuc bao

6. cac phan ung qua man: la co che benh sinh of 1 so benh nh.trung, co hai cho co the

7. su ne tranh dap ung mien dih :

-su an dat of vsv: vsv chui vao trong TB de tranh tac dug of KT va mot so khang sinh

-danh vao he thong mien dich->suy giam he thong mien dich

-VK tiet ra yeu to ngan can va cac cong kich to

-su thay doi KN be mat->han che tac dug of mien dich dac hieu

8. doc luc of VR: la tap hop of nhieu yeu to giup VR nhan len nhanh va gay ton hai TB

-cac yeu to bam va xam nhap

-ngan can su sinh tong hop cac dai phan tu of TB

-lam thay doi tinh tham of lysosom TB->giai phong emzym thuy phan

- lam ton hai mang TB-> thay doi hinh dang va ch/nag of TB

-hinh thanh tieu the noi bao trong TB-> pha huy cau truc va ch/nag TB

-gay bien bang NST

-gay ra chuyen dang TB, loan san TB->khoi U va ung thu