To be extremely honest, I have never played the original Overwatch or Overwatch 2 games as I don't owned a copy and have interested in playing it. I have more interesting in the Overwatch content like the animated shorts and character trailers and also the comics as I enjoy the characters background and personalities. Cinos arrive in the Overwatch universe during the events of Overwatch 2 which take place in 2076. One year later, Overwatch continue to stop Ramattra & his Null Sector and Simon & his Apes and winning against the two faction. Major crossover ship is Wrecker and Odessa until he left with Rex and the rest of the clones to live in the Mega Man universe, Venture meet and become close with Douglas from Mega Man universe very early but short, Mecha Knuckles from Scrapnik Island become close Echo inspired by Mecha Sonic relationship with Kaguya, Gyomei develop a fondness and liking of Illari, and Ramattra meet Seth (SFV) and the two develop very close bond which become romantic. Also sorry for not putting adding the other characters like Emily and Lynx Seventeen in but I want a few associates of Overwatch to be the eyes and ears when they are gone.

As usual once again (this might get very old everytime), Luz, the Calamity Trio, and Molly Jo become close with Sulley and Mike which is my take on DatKaijuFan24 idea but the difference is that she make Salley their monster dad meanwhile I like the idea of him being more of a guardian or babysitter as he's nearly 50 years old and too old to be dad in my opinion and kinda rusty to watch over kids. Cinos never met Luz and Anne in this AU as he only meet the Gravity Fall cast, each of the cast are from one year after their series end as teens and before the huge timeskip as adults.

Notes
Athena is given a body which is Echo's Victorian Doll costume which is knowledgeable as Winston based this new body on Echo. Simon along with Dyson and Calvin are "characters" who are mentioned by Winston from dialogue and from the specimen database who I flesh out as characters who want Earth to be home apes and overthrow humanity, Simon is a gorilla (based on Injustice 2 Gorilla Grodd) who is Winston's Son Wukong costume and Dyson is an orangutan (based on King Louie from the 2016 Jungle Book), I decided to make Calvin a chimp (based on Nesmith from Planet Sheen) as the three are leaders and cybernetically and genetically enhance themselves with powers which is based on the Super Apes from Marvel (I learn and know about them in Hulk and the Agents of S.M.A.S.H.). Some of the Talon members are semi-reform and hesitate to be part of the team as they formed relationship with Overwatch members. Also that Kiriko's father Toshiro was killed by the Hashimoto clan (due to Cinos' interference and presence with this universe's timeline) which made Kiriko heartbroken and try to fight them by herself but used her mother, Akari, and Yoshida as hostage but Cinos arrive as he save the three which results of him chasing and violently kill members of the Hashimoto.

Characters from Monster Inc. (Universe 11-2-1)
Michael "Mike" Wazowski
James Patrick "Sully" Sullivan
Adorable Snowman

Characters from Amphibia (Universe 6-15-12 Earth inhabitants ; Universe 6-17-19 for Amphibia inhabitants)
Anne Savisa Boonchuy & Sasha Elizabeth Waybright
Sprig Plantar & Ivy Sundew
Hopediah "Hop Pop" Plantar
Polly Plantar & Frobo
Grimothy "Grime"
Marceline "Marcy" Regina Wu
Andrias Leviathan
Maddie Flour
Olivia & Yunan Longclaw
Mr. "Bee" & Mrs. "Oum" Boonchuy

Characters from The Owl House (Universe 6-15-12 for Earth inhabitants; Universe 1-10-20 for the The Bowling Isle inhabitants)
Luz Noceda & Amity Blight
Edalyn "Eda" Clawthorne & Raine Whispers
King Clawthorne
Hunter Noceda & Willow Park
Augustus "Gus" Porter
Lilith Clawthorne
Camila Noceda & Darius Deamonne
Alador Blight
Vee Noceda & Masha
Emira "Em" Blight
Edric "Ed" Blight
Eberwolf
Collector "Colly"

Characters from Nanbaka (Universe 10-5-16)
Jyugo & Hitoshi Sugoroku
Uno
Rock & Liang
Nico & Upa
Hajime Sugoroku & Momoko Hyakushiki
Mitsuru Hitokoe
Yamato Godai
Seitaro Tanabata
Enki Gokuu & Noriko Sanzou
Kaguya
Tsukomo & Honey
Musashi
Qi & Tsukomo' adopted mom "Headcanon name Kantoku
Trois & Ruka Gojou
Ikkaku Gokuu

Characters fron School Babysitters (Universe 1-7-18)
Ryuichi Kashima & Maria Inomata
Hayato Kamitani & Yuki Ushimaru
Kotaro Kashima & Kirin Kumatsuka
Taka Kamitani & Takuma Mamizuka
Kazuma Mamizuka & Midori Sawatari
Kichi Nezu
Suekichi Nezu
Kyouko Nezu
Yoshihito Usaida
Usokawa

Characters from Demon Slayer (Universe 4-6-19)
Tanjiro Kamado & Kanao Tsuyuri
Nezuko Kamado & Zenitsu Agatsuma
Inosuke Hashibira & Aoi Kanzaki
Genya Shinazugawa & Muichiro Tokito
Giyu Tomioka & Shinobu Kocho
Kyojuro Rengoku
Tengen Uzui, Makio, Suma, & Hinatsuru
Obanai Iguro & Mitsuri Kanroji
Gyomei Himejima
Sanami Shinazugawa & Kanae Kocho
Senjuro Rengoku, Sumi Nakahara, Naho Takada, & Kiyo Terauchi
Tamayo & Yushiro

Characters from Genshin Impact (Universe 9-28-20)
Aether & Amber
Lumine, Xiao/ Alutus, & Tartaglia/ Ajax/ Childe
Zhongli/ Morax, Ningguang, Beidou, Lisa Minci, Yelan, Raiden Shogun/ Raiden Ei, Yao Miko, Nahida/ Buer, Furina, Navia, Clorinde, Shenhe, Sandrone, Arlecchino, & Asmoday
Albedo & Sucrose
Alhaitham & Kaveh
Baizhu, Vennessa, Xianyun, & Mary-Ann
Venti/ Barbatos & Barbara Pegg
Bennet & Fischl von Luftschloss Narfidort/ Amy
Candace & Layla
Chongyun & Xingqiu
Tighnari & Collei
Cyno & Nilou
Dehya & Dunyarzad
Diluc Ragnvindr & Jean Gunnhildr
Kamisato Ayato & Eula Lawrence
Scaramouche/ Wanderer, Mona Megistus, Faruzan, Kirara, Charlotte, Lynette, Freminet, Lyney, Chevreuse, Gaming, Chiori, & Jeht
Ganyu & Keqing
Gorou & Sangonomiya Kokomi
Hu Tao & Mao Xiangling
Kaedehara Kazuha & Kamisato Ayaka
Kaeya Alberich & Rosaria
Teucer & Klee
Shikanoin Heizou & Kujou Sara
Yanfei & Kuki Shinobu
Mika Schmidt & Paimon
Thoma & Naganohara Yoimiya
Razor & Noelle
Xinyan & Yun Jin
Neuvillette & Wriothesley
Arataki Itto
Qiqi
Diona Katzlein & Sayu
Dori Sangemah Bay & Yaoyao
Sigewinne

Characters from Spy × Family (Universe 4-9-22)
Loid Forger/ Twilight & Yor Forger
Anya Forger & Damian Desmond
Bond Forger
Max
Becky Blackbell
Wiesel
Yuri Briar & Fiona Frost/ Nightfall

Characters from One-Punch Man (Universe 10-5-15)
Saitama, Tatsumaki, & Fubuki
Genos
Isamu/ Child Emperor & Zenko
King
Garou & Kiro
Ino
Tareo
Speed-O-Sound Sonic, Captain Mizuki, Min Min, Suiko, Tank-top Woman, Yuta, Lilly, & Swim

Characters from Overwatch (Universe 5-24-16)
Heroes
Hana Song/ D.Va and Lúcio Correia dos Santos
Orisa and B.O.B.
Reinhardt Wilhelm and Ana Amari
Winston and Athena
Elizabeth Caledonia "Calamity" Ashe and Gabriel Reyes/ Reaper
Bastion and Brigitte Lindholm
Cole Cassidy and Olivia Colomar/ Sombra
Genji Shimada and Angela Ziegler/ Mercy
Hanzo Shimada and Amélie Lacroix/ Widowmaker
Jamison Fawkes/ Junkrat and Mei-Ling Zhou
Fareeha Amari/ Pharah and Satya Vaswani
Vivian Chase/ Sojourn and Noah Venture
Jean-Baptiste Augustin and Niran "Bua" Pruksamanee/ Lifeweaver
Kiriko Kamori and Dae-hyun
Brian and Alejandra
Timmy and Efi Rotìmí Opèyèmi Oluwadaré Gabrielle Oladele
Sieben de Kuiper/ Sigma and Maugaloa Malosi/ Mauga
Zenyatta and Asa Yamagami
Joe and Mary (the omnic-human couple who are background characters who witness Mondatta's death, these are headcanon names DatKaijuFan24 told me about)
John Francis "Jack" Morrison/ Soldier: 76
Mako Rutledge/ Roadhog
Odessa "Dez" Stone/ Junker Queen
Hammond/ Wrecking Ball
Aleksandra Zaryanova/ Zarya
Echo
Torbjörn Lindholm
Lena Oxton/ Tracer
Sloane Cameron/ Venture
Illari
Akari
Murphy
Ganymede

Villains
Ramattra
Simon
Dyson
Calvin
Akende Ogundimu/ Doomfist and Moira O'Deorain

Note
Cinos used for form a romantic relationship with Kiriko during his Isekai adventure as she gave birth to Vulpina.