Note: Just a heads-up, like a number of other titles, I am treating title wins in 2K22 as new reigns, so they will be listed as Reign #1 onwards, but I will also involve any overall reigns including the wins from the games (more specifically in ones I've played so far) and in real life combined.

#1: Mandy Rose [Reign #1/2nd Reign Overall]: She was the first champion in 2K22, so this is being treated as a new reign...just because...

[Days/Weeks Held: 12 Weeks/84 Days - Successful Title Defences: 0].

#2: "The Goddess of WWE" Alexa Bliss [1st Reign/4th Reign Overall]: Won from Mandy Rose at NXT 2.0 in the finals of a Tournament, with Bliss picking up the win after hitting Mandy with "Insult to Injury".

[Days/Weeks Held: 4 Weeks/28 Days - Successful Title Defences: 0].

#3: "The Queen of the Scots" Kay Lee Ray [1st Reign]: Won from Alexa Bliss in a 30-Minute Time Limit, Double Title, 2-out of-3 Falls Match at NXT UK 2020 that was also for Bliss's NXT Women's Championship 2017 to 2022 Version, with Kay Lee winning with the score at 2-0, winning the first fall via pinfall with the "Gory Bomb", and then winning the second fall not too long later with a "Superkick" out of nowhere!

She also held the NXT UK Women's Championship during this reign.

[Days/Weeks Held: 3+ Weeks/21+ Days/Current Champion - Successful Title Defences: 0+].

[As of 21/11/2022].