According to the Kraang, the Utroms, and a few characters, the Mutagen is extremely dangerous, unstable, and unpredictable when they're not in Dimension X.

Cinos, the E-Cryptid series, and even Cinos' 12 daughters developed "Shellacne" which Bishop got the name from Michelangelo but this version is more dangerous as they're melt into mutagen slime. Unfortunately Toadstein is not effective as he does not possess mutagen in his bloodstream due to him being created before the rest. In hope to cure them, Cinos' friends and families ask Baron Draxum in the MHA universe to cured Cinos, his brothers, and his daughters which he need to developed a special Retro-Mutegen to get rid of the sickness. Although Baron Draxum have succeeded to making 13 cure, the dangerous Mechamorph Malware heard of this and took the antidotes in hope of kill Cinos with his brothers and daughters as bonus via his mutagen disease. Although that save the the antidotes, he only save 12 which mean either they give it Cinos' daughters or save the E-Cryptids with only one of his daughters. Cinos instantly decided the answer, give the antidotes to his daughters which the rest of the E-Cryptid series agree with this as Cinos' 12 daughters are finally cured. Baron Draxum quickly try to make a new batch but it was took later, the E-Cryptid slowly burn and melt into a mutagen puddle, Cinos say goodbye to his friends and families as he delivered one last howl at the moon as he now joined his brothers as turn into a mutagen puddle. With everyone sad and depressed, Eggman blamed himself as he responsible of created the E-Cryptid after Cinos to make living weapons to killed Sonic and his friends. While everyone is saddened about the death of Cinos and the E-Cryptid series, Malware deep laugh as he succeeded of killing Cinos with his brothers as bonus although he wishes to do it with his own claws but this a better way to kill your archnemesis.

Inspired by Gargoyle - The Goliath Chronicles episode Genesis Undone and TMNT 2012 Mikey Get Shellacne